Nuestra Senora de Loreto was an important Argentinean Jesuit mission founded in 1610.

Unlike many of its counterparts which had to move several times due to ongoing attacks from slave traders, Nuestra Senora de Loreto only moved once. This resettlement occurred in 1631, when the mission transferred to its present location near Posadas.

While some vegetation has been cleared from the ruins, which include the church, the site is not as well preserved as nearby San Ignacio Mini.